Publications

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BV100
BV200

BV100 Efficacy with ABA

BV100 PKPD poster

BV100 synergy poster

BV200 SA Strain Panel ECCMID2022 poster

Publications

Our Publications

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BV100
BVL-GSK098
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Kevin Antraygues, Mathieu Maingot, Birgit Schellhorn, Vincent Trebosc, Marc Gitzinger, Benoit Deprez, Olivier Defert, Glenn E. Dale, Marilyne Bourotte, Sergio Lociuro, Nicolas Willand

Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration

Science Direct, August 5, 2022

Vincent Trebosc, Christian Kemmer, Sergio Lociuro, Marc Gitzinger, Glenn E. Dale

Rifabutin for infusion (BV100) for the treatment of severe carbapenem-resistant Acinetobacter baumannii infections

Science Direct, September 2021

Valentina Lucchini, Adeline Sivignon, Michel Pieren, Marc Gitzinger, Sergio Lociuro, Nicolas Barnich, Christian Kemmer and Vincent Trebosc

The Role of OmpR in Bile Tolerance and Pathogenesis of Adherent-Invasive Escherichia coli

Frontiers in Microbiology, June 28, 2021

Brian Luna, Vincent Trebosc, Bosul Lee, Malina Bakowski, Amber Ulhaq, Jun Yan, Peggy Lu, Jiagi Cheng, Travis Nielsen, Juheyon Lim, Warisa Ketphan, Hyungjin Eoh, Case McNamara, Nicholas Skandalis, Rosemary She, Christian Kemmer, Sergio Lociuro, Glenn E. Dale and Brad Spellberg.

A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumanii

Nature Microbiology, September 5, 2020

Vincent Trebosc, Birgit Schellhorn, Julian Schill, Valentina Lucchini, Jaqueline Bühler, Marilyne Bourotte, Jonathan J. Butcher, Marc Gitzinger, Sergio Lociuro, Christian Kemmer and Glenn E. Dale.

In vitro actitvity of rifabutin against 293 contemporary carbapeneme-resistant Acinetobachter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms

Journal of Antimicrobial Chemotherapy (JAC), September 1, 2020

Vincent Trebosc, Sarah Gartenmann, Marcus Tötzl, Valentina Lucchini, Birgit Schellhorn, Michel Pieren, Sergio Lociuro, Marc Gitzinger, Marcel Tigges, Dirk Bumann, Christian Kemmer

Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates

American Society for Biology, July 16, 2019

Pastor, A; Machelart, A; Li, X; Willand, N; Baulard, A; Brodin, P; Gref, R; Desmaele, D

A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation

Organic & Biomolecular Chemistry, May 2, 2019

Arnaud Machelart , Giuseppina Salzano, Xue Li, Aurore Demars, Anne-Sophie Debrie, Mario Menendez-Miranda, Elisabetta Pancani, Samuel Jouny, Eik Hoffmann, Nathalie Deboosere, Imène Belhaouane, Carine Rouanet, Sophie Simar, Smaïl Talahari, Valerie Giannini, Baptiste Villemagne, Marion Flipo, Roland Brosch, Fabrice Nesslany, Benoit Deprez, Eric Muraille, Camille Locht, Alain R. Baulard, Nicolas Willand, Laleh Majlessi, Ruxandra Gref*, and Priscille Brodin*

Intrinsic Antibacterial Activity of Nanoparticles Made of beta-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis

Acs Publications, March 1, 2019

Hugues Preveta, Martin Mouneb, Abdalkarim Taninac, Christian Kemmerd, Adrien Herledana, Rosangela Frita, Alexandre Wohlkönige, Marilyne Bourotte, Baptiste Villemagnea, Florence Lerouxa, Marc Gitzinger, Alain R.Baulard, Benoit Dépreza, René Wintjens, Nicolas Willand, Marion Flipo

A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2

European Journal of Medicinal Chemistry, Feburary 10, 2019

Abdalkarim Tanina, Alexandre Wohlkönig, Sameh H Soror, Marion Flipo, Baptiste Villemagne, Hugues Prevet, Benoit Déprez, Martin Moune, Hélène Perée, Franck Meyer, Alain R Baulard, Nicolas Willand, René Wintjens

A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, March, 2019

Olivier Cunrath, Dominik M. Meinel, Pauline Maturana, Joseph Fanous, Julien M. Buyck, Pamela Saint Auguste, Helena M.B. Seth-Smith, Jonas Körner, Christoph Dehio, Vincent Trebosc, Christian Kemmer, Richard Neher, Adrian Egli, Dirk Bumann. Quantitative Contribution of Efflux to Multi-drug Resistance of Clinical Escherichia coli and Pseudomonas aeruginosa Strains. EBioMedicine, Volume 41, March 2019, Pages 479-487,

Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains

EBio Medicine, March 6, 2019

MarionPrieria, RosangelaFrita, Nicolas Probsta, Alix Sournia-Saquetc, Marilyne Bourotte, Benoit Déprez, Alain R.Baulard, Nicolas Willand

Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis

European Journal of Medicinal Chemistry, September 20, 2018

Camilo Barbosa, Vincent Trebosc, Christian Kemmer, Philip Rosenstiel, Robert Beardmore, Hinrich Schulenburg, Gunther Jansen

Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects

Molecular Biology and Evolution, September 9, 2017

Joana Costa-Gouveia, Elisabetta Pancani, Samuel Jouny, Arnaud Machelart, Vincent Delorme, Giuseppina Salzano, Raffaella Iantomasi, Catherine Piveteau, Christophe J Queval, Ok-Ryul Song, Marion Flipo, Benoit Deprez, Jean-Paul Saint-André, José Hureaux, Laleh Majlessi, Nicolas Willand, Alain Baulard, Priscille Brodin, Ruxandra Gref

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

Scientific Reports, May 10, 2018

Nicolas Blondiaux, Martin Moune, Matthieu Desroses, Rosangela Frita, Marion Flipo, Vanessa Mathys, Karine Soetaert, Mehdi Kiass, Vincent Delorme, Kamel Djaout, Vincent Trebosc, Christian Kemmer, René Wintjens, Alexandre Wohlkönig, Rudy Antoine, Ludovic Huot, David Hot, Mireia Coscolla, Julia Feldmann, Sebastien Gagneux, Camille Locht, Priscille Brodin, Marc Gitzinger, Benoit Déprez, Nicolas Willand, Alain R Baulard

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420

Science, March 26, 2017

Dr. Geoffroy Dequirez, Dr. Marilyne Bourotte, Dr. Esther Porras de Francisco, Dr. Modesto J. Remuiñan Blanco, Dr. Benoit Déprez, Dr. Nicolas Willand

Microwave-Assisted Suzuki-Miyaura Cross Coupling using Nickel as Catalyst to Rapidly Access to 3-Arylazetidine

Chemistry Europe, October 2, 2017

Vincent Trebosc, Sarah Gartenmann, Kevin Royet, Pablo Manfredi, Marcus Tötzl, Birgit Schellhorn, Michel Pieren, Marcel Tigges, Sergio Lociuro, Peter C. Sennhenn, Marc Gitzinger, Dirk Bumann, Christian Kemmer

A Novel Genome-Editing Platform for Drug-Resistant Acinetobacter baumannii Reveals an AdeR-Unrelated Tigecycline Resistance Mechanism

American Society for Microbiology, November 21, 2016

Marcel Tigges, Marc Gitzinger

BioVersys Works to Bring Antibiotic Resistance to an End

Chimia, December 12, 2014

Michel Pieren, Marcel Tigges

Adjuvant strategies for potentiation of antibiotics to overcome antimicrobial resistance

Current Opinion in Pharmacology, July 25, 2012

Thomas Grau, Petra Selchow, Marcel Tigges, Reto Burri, Marc Gitzinger, Erik C Böttger, Martin Fussenegger, Peter Sander

Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosis

Antimicrobial Agents Chemotherapies (AAC), November 21, 2011

Nicolas Willand, Bertrand Dirié, Xavier Carette, Pablo Bifani, Amit Singhal, Matthieu Desroses, Florence Leroux, Eve Willery, Vanessa Mathys, Rebecca Déprez-Poulain, Guy Delcroix, Frédéric Frénois, Marc Aumercier, Camille Locht, Vincent Villeret, Benoit Déprez, Alain R Baulard

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

Nature Medicine, May 3, 2009

Wilfried Weber, Ronald Schoenmakers, Bettina Keller, Marc Gitzinger, Thomas Grau, Marie Daoud-El Baba, Peter Sander, Martin Fussenegger

A synthetic mammalian gene circuit reveals antituberculosis compounds

Proc Natl Acad Sci USA (PNAS), July 9, 2008